Objective: This paper presents a cross-sectional study aimed at evaluating the relationship between meaning of life and quality of life (QOL) in Chinese patients with hematologic neoplasms (HN). Methods: Overall, 190 HN patients were screened for inclusion in the single-center study. Each participant completed the Meaning in life questionnaire scale (MLQ) and Functional Assessment of Cancer Therapy (FACT-G). Correlation analyses between the overall scores of each of the instruments were conducted. Results: The total score of MLQ in HN patients was 43.47±9.48, and factor scores of presence and search were 22.86±5.56 and 20.61±4.97, respectively. The total score of FACT-G was 46.81±14.32, and factor scores of physical, social-family, emotional well-being and functional were: 9.79±6.60, 17.89±6.06, 7.34±5.14, 11.84±6.57, respectively. The total score of MLQ positively correlated with the score of FACT-G (r=0.27, P=0.02). Conclusion: Our findings support the hypothesis that participants who have a strong perception of the meaning of life tend to report higher levels of quality of life. We recommend that perceived meaning of life be more specifically examined in the cancer and palliative care settings.