Objective: To investigate and analyze the degree of care and intervention of front-line night nurses for the sleep condition of inpatients. Methods: Using the self-designed sleep care questionnaire, 316 clinical front-line night nurses from six first-class hospitals in Changsha were investigated by questionnaire. Results: From our investigation, 91.8% of the nurses were concerned about the sleep condition of the inpatients. 97.8% of the nurses think sleep condition has great influence on the recovery of other diseases, 83.6% of the nurses could actively understand the causes of sleep disorders in patients, but there are 27.2% of the nurses; occasionally, or never help improve or solve patients’ insomnia, 29.4% of nurses occasionally, or never contact sleep education on patients with sleep disorders. A comparative analysis was conducted on the management behaviors of sleep care degree and sleep quality of patients by nurses of different ages, departments, working years, professional titles and educational levels, the results showed that the different working years had statistically significant in sleep care and sleep education (P<0.05). Conclusion: The nurses show a positive attitude to the caring and intervention of inpatients’ sleeping, and they have realized the importance of sleeping to the recovery of illnesses. Actions have been taken to improve the sleeping quality of inpatients actively. However, around one third of nurses don’t help to improve or solve the inpatients’ sleeping disorders, among whom most are with a short length of service. In future, Nursing management should pay more attention to the training of nurses on patients’ sleep care, especially the front-line night shift nurses should be the key intervention object. It is supposed to improve the standardized sleep assessment tools and form a standardized intervention system,which could guide nurses to take effective measures to improve the sleep quality of inpatients and promote the early recovery of patients.