金属蛋白酶在皮肤光老化信号通路中的研究进展
| 作者: |
1林芳,
1马良娟
1 哈尔滨医科大学附属第二医院皮肤性病科，哈尔滨 150001 |
| 通讯: |
马良娟
Email: maliangjuan@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.11.033 |
| 基金: | 国家自然科学基金(81502706)。 |
摘要
皮肤光老化(skin photoaging)是指皮肤长期受紫外线(ultraviolet，UV)辐射引起的皮肤老化。紫外线照射后诱导产生活性氧，活性氧可以通过多条信号通路转导，使有活性的基质金属蛋白酶(matrix metalloproteases，MMPs)过度表达。MMPs在胶原蛋白降解过程中起关键作用，其主要生物学特征是真皮中成纤维细胞功能受到破坏，合成和分泌胶原蛋白的能力下降，特异性降解细胞外基质成分，破坏胶原蛋白(纤维)的正常结构，最终导致皮肤光老化。
关键词：
紫外线；皮肤光老化；金属蛋白酶；信号通路
Research progress of metalloproteinases in signaling pathways of photoaging of skin
CorrespondingAuthor: MA Liangjuan Email: maliangjuan@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.11.033
Foundation: This work was supported by the National Natural Science Foundation of China (81502706).
Abstract
Skin photoaging refers to the skin’s long-term skin aging caused by ultraviolet (UV) radiation. UV irradiation induces the production of reactive oxygen species, which can be transmitted through multiple signaling pathways to overexpress active matrix metalloprotes (MMPs). MMPs play a key role in collagen degradation, and its main biology is characterized by the destruction of fibroblast function in the dermis, the decreased ability to synthesize and secrete collagen, the specific degradation of extracellular matrix components, the destruction of the normal structure of collagen (fiber), and ultimately the photoaging of the skin.
Keywords：
ultraviolet; skin photoaging; matrix metalloproteinase; signal pathway