超声造影在非霍奇金淋巴瘤中的应用进展
作者: |
1王猛,
1周晓莹,
1王立新
1 吉化集团公司总医院电诊科,吉林 吉林 132021 |
通讯: |
王立新
Email: wanglixinjh@126.com |
DOI: | 10.3978/j.issn.2095-6959.2018.09.034 |
摘要
淋巴瘤是淋巴造血系统常见恶性肿瘤之一,非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)是其主要类型(约占80%)。NHL是一组在临床表现、分子发病机制及治疗反应等方面均存在高度异质性的疾病。NHL可起源于淋巴结,也可原发于节外器官。影像学检查在淋巴瘤的诊断、鉴别诊断及病情监测方面均具有重要的指导意义。超声造影显像(contrast-enhanced ultrasonography,CEU)不仅可以显示器官组织的微小结构,而且可显示其血流灌注状态。通过使用造影剂,CEU可实现信号放大,同时联合定性(强化类型等)及定量(时间强度曲线等)分析,可区分病灶的良恶性及鉴别不同类型恶性肿瘤。因而,CEU在淋巴瘤治疗后疗效评估及原发节外器官淋巴瘤的诊断及鉴别诊断方面具有一定的优势。
关键词:
淋巴瘤;非霍奇金淋巴瘤;超声造影显像
Research progress of application contrast-enhanced ultrasonography in non-Hodgkin lymphoma
CorrespondingAuthor: WANG Lixin Email: wanglixinjh@126.com
DOI: 10.3978/j.issn.2095-6959.2018.09.034
Abstract
Lymphoma is one of the most common malignant neoplasms of lymphohematopoietic system, and non-Hodgkin lymphoma (NHL) is the major type (approximately 80%) of lymphoma. NHL is a group of highly heterogeneous diseases in terms of clinical manifestations, molecular pathogenesis mechanisms, and responses to treatment. NHL can originate from lymph node or extranodual organs. Imaging examinations play important roles in guiding diagnosis, differential diagnosis, and disease monitoring of lymphoma after treatment. Contrast-enhanced ultrasound (CEU) not only shows small structure of organs, but also displays their blood perfusion state. Signal enhancement can be realized in CEU examination via using contrast agents. By combining quantitative (e.g., enhancement patterns) and qualitative (e.g., intensity-time curves) analysis, CEU can distinguish malignant diseases from benign lesions, and make differential diagnosis of different malignant tumors. Therefore, CEU has some advantages in monitoring therapeutic effect of lymphoma, and in diagnosis, differential diagnosis of primary extranodual lymphoma.
Keywords:
lymphoma; non-Hodgkin lymphoma; contrast-enhanced ultrasonography