巨噬细胞在糖尿病胃轻瘫中的研究进展
| 作者: |
1李雅清,
1,2李慧,
1安振涛,
1,2田耀洲
1 南京中医药大学第三临床医学院，南京 210028 2 江苏省中西医结合医院消化内科，南京 210028 |
| 通讯: |
田耀洲
Email: 584249042@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.033 |
| 基金: | 国家自然科学基金(81603586)；江苏省自然科学基金(BK20151046)。 |
摘要
糖尿病胃轻瘫(diabetic gastroparesis，DGP)的组织学改变包括Cajal间质细胞(Cajal interstitial cells， ICC)的神经元、平滑肌细胞以及间质细胞的损伤等。DGP病程发展过程中胃部组织学的改变日益受到重视，而巨噬细胞是DGP发病机制中的关键因素，巨噬细胞的不同表型及其表型之间的动态平衡与DGP中胃轻瘫的进展关系密切，是决定DGP发展进程的重要因素。
关键词：
糖尿病胃轻瘫；巨噬细胞分型；动态平衡
Research progress of macrophages in diabetic gastroparesis
CorrespondingAuthor: TIAN Yaozhou Email: 584249042@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.09.033
Foundation: This work was supported by the National Natural Science Foundation (81603586) and the Jiangsu Provincial Natural Science Foundation (BK20151046), China.
Abstract
Histological changes in diabetic gastroparesis (DGP) include damage to neurons, smooth muscle cells and mesenchymal cells in Cajal mesenchymal cells (ICC). The changes in gastric histology during the development of DGP have been paid more and more attention, and macrophages are the key factors in the pathogenesis of DGP. The dynamic balance between different phenotypes and phenotypes of macrophages is closely related to the progress of gastroparesis in DGP, which is an important factor determining the development of gastroparesis in DGP.
Keywords：
diabetic gastroparesis; macrophage typing; dynamic homeostasis