贵州地区克罗恩病发病的危险因素
| 作者: |
1,2崔德军,
1,3杨柳婵,
3杨小兰,
1韩然,
1,3袁文强,
1张曼曼
1 贵州省人民医院消化内科，贵阳 550002 2 贵州大学医学院，贵阳 550025 3 贵州医科大学附属人民医院消化内科，贵阳 550002 |
| 通讯: |
崔德军
Email: hxcuidj@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.016 |
| 基金: | 贵州省卫生和计划生育委员会科学技术基金 (gzwjkj2016-1-004)；贵州省人民医院博士基金 [GZSYBS(2017)09]；北京医卫健康公益基金会医学科学研究基金 (YWJKJJHKYJJ-B184053)。 |
摘要
目的：探索克罗恩病(Crohn ’ s d i sea se，CD)发病的危险因素。方法：采用1 : 1配对病例对照研究。采用t检验、χ 2检验、单因素、多因素条件log i st ic回归分析CD与对照组的相关危险因素。 结果：单因素分析显示西餐、蔬菜水果、饮酒、居住条件与CD发病有关(P<0.20)。多因素分析显示仅西餐为CD发病的危险因素(P=0.015，OR=12.729，95%CI 1.656~97.855)。结论：进食西餐可能为贵州地区CD发病的危险因素。
关键词：
克罗恩病；炎症性肠病；危险因素；病例对照研究
Risk factors of Crohn’s disease in Guizhou population
CorrespondingAuthor: CUI Dejun Email: hxcuidj@163.com
DOI: 10.3978/j.issn.2095-6959.2018.09.016
Foundation: This work was supported by Science and Technology Foundation of Health and Family Planning Commission of Guizhou Province (gzwjkj2016-1-004), Doctor Foundation of Guizhou Provincial People’s Hospital [GZSYBS(2017)09] and Beijing Medical and Health Foundation (YWJKJJHKYJJ-B184053)
Abstract
Objective: To explore the potential risk factors in the development of Crohn’s disease (CD). Methods: A matched case-control (1:1) study was designed. T test, Chi-square test, conditional logistic regression was used to comparatively analyze the potential risk factors between CD patients and the controls. Results: Univariate analysis showed that western food, fruits and vegetables, alcohol drinking, and housing condition were statistically correlated with CD (P<0.20). However, multivariate logistic regression analysis indicated that western food was only risk factor of CD in Guizhou population (P=0.015, OR=12.729, 95%CI 1.656–97.855). Conclusion: Western food may be a risk factor in the pathogenesis of CD in Guizhou population.
Keywords：
Crohn’s disease; inflammatory bowel disease; risk factor; case-control study