59 例早期胎传梅毒的临床特征分析
| 作者: |
1陈亚玲,
1胡志亮,
2陈伟,
1池云,
1成骢,
1魏洪霞
1 东南大学附属第二医院感染病科，南京 210003 2 东南大学附属第二医院临床科研中心，南京 210003 |
| 通讯: |
魏洪霞
Email: wghongxia@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.015 |
| 基金: | 国家自然科学基金青年基金 (NFSC 81701973)；江苏省“十三五科教强卫工程”青年医学重点人才项目 (QNRC2016059)；南京市医学科技发展重点项目 (ZKX17040)。 |
摘要
目的：探讨早期胎传梅毒的临床表现，以提高对早期胎传梅毒的识别。方法：回顾性分析东南大学附属第二医院感染病科2007年3月至2016年5月收治的早期胎传梅毒的病历资料。结果：共有59例患者纳入分析，年龄0.17~19(中位2)个月，入院时血清RPR滴度为1:1~1:512(中位1:16)。该59例患者中，98.31%(58/59)可能存在梅毒相关损害；皮疹、贫血、肝损、骨损害以及脑脊液异常患者所占比例分别为40.68%(24/59)，32.20%(19/59)，66.10%(39/59)，43.3%(13/30)， 50%(8/16)。结论：早期胎传梅毒多于出生后半年内出现症状，常损害皮肤、肝、脾、骨骼、神经系统等多脏器功能。确诊为胎传梅毒后，建议积极腰穿排除神经梅毒。
关键词：
先天性梅毒；早期胎传梅毒；神经梅毒；临床特征
Analysis of clinical features of 59 cases of early congenital syphilis
CorrespondingAuthor: WEI Hongxia Email: wghongxia@sina.com
DOI: 10.3978/j.issn.2095-6959.2018.09.015
Foundation: This work was supported by the National Natural Science Foundation (NFSC 81701973), Project of Jiangsu Province Medical Youth Talent (QNRC2016059) and Nanjing Medical Science and Technique Development Foundation (ZKX17040)
Abstract
Objective: To explore the clinical manifestations of early congenital syphilis in order to improve the identification of early congenital syphilis. Methods: This study retrospectively analyzed the medical records of the early congenital syphilis treated at the Department of Infectious Diseases of the Second Hospital Affiliated to Southeast University from March 2007 to May 2016. Results: A total of 59 patients were included in the analysis, with a median (range) age of 2 (0.17–19) months. The median (range) serum RPR titer at admission was 1:16 (1:1–1:512). Of the 59 patients, 98.31% (58/59) had syphilis-related lesions; the proportions of patients with rash, anemia, liver damage, bone damage, and cerebrospinal fluid abnormalities were 40.68% (24/59), 32.20% (19/59), 66.10% (39/59), 43.3% (13/30) and 50% (8/16). Conclusion: Early congenital syphilis occurs within half a year after birth and often impairs multiple organ functions such as skin, liver, spleen, bone, and nervous system. After the diagnosis of early congenital syphilis, it is recommended to actively exclude lumbar nerve syphilis.
Keywords：
congenital syphilis; early congenital syphilis; neurosyphilis; clinical features