Objective: To observe the metabolic changes in patients with prostate cancer (PCa) who received maximum androgen blockade, and to compare the effects of intermittent and continuous strategies. Methods: Seventy-six PCa patients receiving maximum androgen blockade from January 2013 and January 2016 in Zhuhai People’s Hospital and in accordance with the inclusion criteria were retrospectively analyzed, in which 36 patients were treated with intermittent hormonal therapy (IHT) strategy (Group IHT) and 40 patients were treated with continuous hormonal therapy (CHT) strategy (Group CHT). The changes of BMI, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), TG, TC, HDL and LDL before the treatment, 12 and 24 months after the treatment were analyzed. Results: In Group IHT, BMI and WC increased consistently within 24 months; blood pressure, FBG and TG were higher after treatment than that before the treatment, while no significant change was seen between 12 and 24 months after the treatment; TC increased at 12 months after the treatment, while at 24 months the level was the same as that before the treatment; the changes of HDL and LDL were not significant before and after the treatment. In Group CHT, BMI, waist circumference, blood pressure and FBG increased consistently within 24 months; TG and TC were on a higher level post-treatment, while no significant change was seen between the two time points. HDL did not change in 12 months, while decreased in 24 months. LDL remained stable within 24 months. In 12 months, there were no significant difference in all the indexes between the two groups, while in 24 months, except for LDL, the changes of indexes in Group IHT were smaller than that in Group CHT. Conclusion: Both IHT and CHT strategies of MAB caused metabolic disorders at different degrees, but IHT was better than CHT in the long-term treatment.