Objective: To optimize the shunt management strategy for Atypical squamous cell of undetermined significance (ASCUS) patients with no clear diagnostic results. Methods: High-risk human papillomavirus (HPV) testing, colposcopy, cervical multipoint biopsy, or endocervical scraping were performed on 118 patients with ASCUS screening results. HPV test results, colposcopic findings, and histopathology were analyzed. Results: HPV had high sensitivity (100%) but poor specificity (35.8%) in the diagnosis of cervical lesions. Therefore, a single random screening of HPV cannot be used as the main method to guide diagnosis and treatment. Patients with thinprep cytologic test (TCT) diagnosed as ASCUS performed colposcopy directly if they were unconditionally tested for hr-HPV. The rate of complete coincidence with pathological findings was high (78.0%). For patients with a score of 1 to 2 points, they can communicate with the patient and decide whether to take a biopsy or recheck TCT after 4–6 months. Patients with a score of ≥3 should take a biopsy to avoid missed diagnosis. Conclusion: Colposcopy Reid score can effectively evaluate the prognosis of ASCUS pat ients.