消化性溃疡患者血清α 防御素，visfatin，IL-17 的表达及意义
| 作者: |
1陈思宇,
1张强,
2李妍
1 重庆市长寿区人民医院消化内科，重庆 401220 2 陆军军医大学附属第一人民医院消化内科，重庆 400000 |
| 通讯: |
陈思宇
Email: changshouhu8@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.005 |
摘要
目的：分析消化性溃疡患者血清α防御素(alpha defensin，DEFA)、内脂素(visfatin)，IL -17的表达及意义。方法：选择重庆市长寿区人民医院2016年3月至2018年3月收治的102例消化性溃疡患者，按疾病类型、幽门螺杆菌(helicobacter pylori，Hp)情况、病情程度分为不同组别，并同期选择95例健康体检者做为对照组。比较各组血清DEFA，visfatin，IL -17水平，并分析其相关性和诊断效能。结果：消化性溃疡组血清DEFA水平低于对照组，血清v isfatin，IL -17水平高于对照组(P<0.05)。复合性溃疡组血清DEFA水平低于胃溃疡组及十二指肠溃疡组，血清visfatin，IL -17水平高于胃溃疡组及十二指肠溃疡组(P<0.05)。消化性溃疡Hp阴性组血清DEFA水平高于HP I型组及HP II型组(P<0.05)；血清visfatin，IL -17水平高于HP高型组及HP及型组(P<0.05)。消化性溃疡患者活动期血清DEFA低于愈合期且低于疤痕期，visfatin，IL -17水平高于愈合期且高于疤痕期(P<0.05)。消化性溃疡患者血清DEFA和visfatin呈负相关，DEFA和IL -17呈负相关(r分别为−0.526，−0.654)，visfatin和IL -17呈正相关(r为0.404)。受试者工作特征(receiver-operating characteristic，ROC)曲线显示：血清DEFA水平诊断曲线下面积(area under curve，AUC)为0.756，visfatin水平诊断AUC为0.652，IL -17水平诊断AUC为0.830，DEFA+visfatin+IL -17水平诊断AUC为0.892。结论：DEFA，visfatin及IL -17均可参与消化性溃疡发病，其水平改变可能和炎症程度有关，可作为临床重要的观察指标。
关键词：
消化性溃疡；α防御素；内脂素；白介素-17；表达
Expression and significance of serum DEFA, visfatin and IL-17 in patients with peptic ulcer
CorrespondingAuthor: CHEN Siyu Email: changshouhu8@163.com
DOI: 10.3978/j.issn.2095-6959.2018.09.005
Abstract
Objective: To analyze the expression and significance of serum alpha defensin (DEFA), visfatin and interleukin-17 (IL-17) in patients with peptic ulcer. Methods: One hundred and two patients with peptic ulcer patients who treated from March 2016 to March 2018 in People’s Hospital of Chongqing Changshou, according to the disease type, helicobacter pylori (Hp) situation, disease degree were divided into different groups, at the same time, 95 healthy subjects were selected as the control group. Serum DEFA, visfatin and IL-17 levels of each group were compared, the correlation and diagnostic efficiency were also analyzed. Results: Serum levels of DEFA in the peptic ulcer group were lower than those in the control group, while the serum levels of visfatin and IL-17 were higher than those in the control group (P<0.05). Serum levels of DEFA in compound ulcer group were lower than those of gastric ulcer group and duodenal ulcer group, while the serum levels of visfatin and IL-17 were higher than those of gastric ulcer group and duodenal ulcer group (P<0.05). Serum levels of DEFA in peptic ulcer Hp negative group were higher than HP I group and HP II group (P<0.05), the level of serum visfatin, IL-17 were higher than HP those of gastric ulcer (P<0.05). Serum levels of DEFA in active stage of patients with peptic ulcer was lower than healing stage and lower than scar stage, levels of visfatin and IL-17 were higher than healing stage and higher than scar stage (P<0.05). Serum DEFA and visfatin were negatively correlated in patients with peptic ulcer, while DEFA and IL-17 were negatively correlated (r was −0.526 and −0.654), and visfatin and IL-17 were positively correlated (r was 0.404). Receiver-operating characteristic (ROC) curve drawing, serum level of DEFA diagnosis area under curve (AUC) was 0.756, visfatin level in the diagnosis of AUC was 0.652, IL-17 AUC was 0.830, DEFA + visfatin + IL-17 visfatin level diagnosis was 0.892. Conclusion: DEFA, visfatin and IL-17 can all be involved in the incidence of peptic ulcer, Changes in their levels may be related to the degree of inflammation, can be used as an important clinical observation.
Keywords：
peptic ulcer; alpha defensin; visfatin; interleukin-17; express