EGFR 和HER-3 在老年胃癌组织中的表达及其与预后的关系
| 作者: |
1徐磊,
1孙志超,
2冯晓星
1 连云港市第二人民医院病理科，江苏 连云港 222002 2 无锡市第三人民医院病理科，江苏 无锡 214041 |
| 通讯: |
徐磊
Email: xuleineil@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.004 |
摘要
目的：探讨表皮生长因子受体EGFR和HER-3在老年胃癌中的表达及其与预后的关系，为老年胃癌的临床靶向治疗提供理论依据。方法：应用免疫组织化学方法检测62例老年胃癌组织中EGFR和HER-3的表达情况，并统计分析EGFR和HER-3的表达与患者临床病理特征的关系及其对预后的影响。结果：EGFR在细胞膜和/或细胞质表达，HER-3在细胞膜表达。EGFR的阳性表达与患者的性别、肿瘤大小、肿瘤分化程度无关(P>0.05)，而与肿瘤侵犯层次、淋巴结转移及TNM分期密切相关(P<0.05)。HER-3的阳性表达与患者的性别、肿瘤大小、侵犯层次无关(P>0.05)，而与肿瘤分化程度、淋巴结转移及TNM分期密切相关(P<0.05)。Spearman相关性分析结果表明EGFR的表达和HER-3的表达无相关性(r=−0.015，P=0.908)。Kaplan-Meier生存分析显示EGFR，HER-3阳性表达的患者3年生存率均明显低于阴性表达者(P<0.05)。Cox风险回归多因素生存分析显示EGFR阳性表达(P=0.012)、淋巴结转移(P=0.038)、TNM分期(P=0.011)是影响老年胃癌患者生存的独立预后因素。结论：EGFR和HER-3的阳性表达与老年胃癌的临床病理特征及预后密切相关，两者可作为评估老年胃癌预后的参考指标。
关键词：
老年胃癌；EGFR；HER-3；预后
Expression of EGFR and HER-3 in elderly patients with gastric cancer and its association with the prognosis
CorrespondingAuthor: XU Lei Email: xuleineil@163.com
DOI: 10.3978/j.issn.2095-6959.2018.09.004
Abstract
Objective: To investigate the expressions of EGFR and HER-3 protein in elderly patients with gastric cancer and its association with the prognosis. Methods: The expressions of EGFR and HER-3 protein in 62 elderly patients with gastric cancer were detected by immunohistochemical staining. The prognosis and the clinicopathologic characters with the relation of the expressions of EGFR and HER-3 protein were analyzed. Results: EGFR were expressed on the cell membranes or cytoplasm and HER-3 was expressed on the membranes. No correlation was found in EGFR with gender, tumor size, and cell differentiation (P>0.05). However, EGFR was associated with lymph nodes metastasis, tumor invasion level and TNM stage (P<0.05). HER-3 was associated with lymph nodes metastasis, TNM stage and cell differentiation (P<0.05). And it had no relation in HER-3 with gender, tumor size, and tumor invasion level. The Spearman rank correlation analysis showed that there was no correlation between the expressions of EGFR and HER-3 protein (r=−0.015, P=0.908). Kaplan-Meier survival analysis revealed that 3-year survival rate of patients with positive expression of EGFR or HER-3 were shorter than negative patients (P<0.05). Multivariate analysis with the Cox regression models showed that expression of EGFR protein (P=0.012, lymph node metastasis (P=0.038) and TNM stage (P=0.011) were significantly associated with poor prognosis. Conclusion: The expressions of EGFR and HER-3 are related to the prognosis and the clinicopathologic characters of elderly patients with gastric cancer. They could be the index of the prognosis for elderly patients with gastric cancer.
Keywords：
elderly patients with gastric cancer; EGFR; HER-3; prognosis