原发性子宫内膜小细胞神经内分泌癌1例并文献复习
| 作者: |
1肖川,
1王晨晨,
1沈铭红,
1吕京澴
1 南京医科大学附属苏州医院，苏州市立医院病理科，江苏 苏州 215002 |
| 通讯: |
吕京澴
Email: jhlv@njmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2018.08.037 |
摘要
子宫内膜小细胞神经内分泌癌(small cell neuroendocrine carcinoma，SCNEC)是一种罕见的具有侵袭性的疾病，预后极差。本文报道的1例54岁绝经后妇女，因阴道出血、腹痛入院，超声提示子宫肌瘤多发，子宫增大。患者行全子宫切除术，双侧输卵管、卵巢切除术和膀胱前病灶切除术。病理结果为原发性子宫内膜SCNEC，妇产科联盟(Federation of Gynecology and Obstetrics，FIGO)2008分期至少为IIIA期。患者未进行淋巴结清扫，在接受7个周期的化学治疗(以下简称化疗)后无病生存8个月。目前临床上针对这种罕见的侵袭性疾病的最佳治疗方案尚未建立，需要个体化的多学科综合治疗。
关键词：
小细胞神经内分泌癌；子宫内膜；超声；免疫组织化学染色
Primary small cell neuroendocrine carcinoma of endometrium: a case report and review of literature
CorrespondingAuthor: LÜ Jinghuan Email: jhlv@njmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2018.08.037
Abstract
Primary small cell neuroendocrine carcinoma (SCNEC) of the endometrium is a rare disease with an aggressive behavior and has a very poor prognosis. We presented a case of a 54-year-old postmenopausal woman with vaginal bleeding and abdominal pain. She underwent a radical abdominal hysterectomy with bilateral salpingo-oophorectomy and the lesionectomy on the front of the bladder. The pathological diagnosis was SCNEC and the Federation of Gynecology and Obstetrics (FIGO 2008) stage was at least IIIA. The patient is currently healthy without evidence of disease for 8 months after received chemotherapy for 7 cycles without lymphadenectomy. To date, the optimal treatment for this rare and aggressive disease has not been established and requires an individualized multidisciplinary management.
Keywords：
small cell neuroendocrine carcinoma; endometrium; ultrasound; immunohistochemical staining