PAX-5在非淋巴造血系统肿瘤中的研究进展
| 作者: |
1曹石,
2李文生
1 西安医学院，西安 710068 2 陕西省人民医院病理科，西安 710068 |
| 通讯: |
李文生
Email: liwensheng263@sohu.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.08.030 |
| 基金: | 陕西省重点研发计划项目(2017-SF091)。 |
摘要
PAX-5基因是PAX基因(paired box gene)家族的一员，其编码的蛋白被称为B细胞特异性激活蛋白(B cell specific activator protein，BSAP)，在B细胞的生长和发育过程中具有重要的作用。PAX-5在B淋巴细胞及其来源的肿瘤中可高表达，尤其是B淋巴母细胞淋巴瘤，是一种用于淋巴造血系统肿瘤诊断与鉴别诊断的可靠标志物。近年来研究发现PAX-5可在淋巴造血系统外的恶性肿瘤中异常表达，例如神经内分泌肿瘤(Merkel细胞癌、小细胞癌和大细胞神经内分泌癌、胃肠道神经内分泌肿瘤)、乳腺癌、肝细胞癌、膀胱癌、星形细胞瘤、髓母细胞瘤、口腔鳞状细胞癌等，造成某些淋巴造血系统肿瘤诊断及鉴别诊断的困难，而且PAX-5与某些恶性肿瘤的进展、转移及预后有关。因此，研究PAX-5在非淋巴造血系统肿瘤中的表达具有重要意义。
关键词：
PAX-5；非淋巴造血系统；肿瘤
Research progress of PAX-5 expression in non-lymphoid hematopoietic system tumors
CorrespondingAuthor: LI Wensheng Email: liwensheng263@sohu.com
DOI: 10.3978/j.issn.2095-6959.2018.08.030
Foundation: This work was supported by the Shaanxi Provincial Key Research and Development Foundation, China (2017-SF091).
Abstract
PAX-5 gene is a member of PAX gene family. The encoded protein of PAX-5 is called B cell specific activator protein (BSAP) and plays an important role in the growth and development of B cells. PAX-5 is highly expressed in B lymphocytes and their derived tumors, especially in B lymphoblastic lymphomas. It is a reliable marker for the diagnosis and differential diagnosis of lymphoid hematopoietic system tumors. In recent years, studies have found that PAX-5 can be abnormally expressed in malignant tumors outside the lymphatic hematopoietic system, such as neuroendocrine tumors (Merkel cell carcinoma, small cell carcinoma and large cell neuroendocrine carcinoma, gastrointestinal neuroendocrine tumor), breast carcinoma, hepatocellular carcinoma, bladder cancer, astrocytoma, medulloblastoma, oral squamous cell carcinoma and it is related to the progression, metastasis and prognosis of certain malignant tumors. Therefore, it is of great significance to study the expression of PAX-5 in non-lymphoid hematopoietic system tumors.
Keywords：
PAX-5; non lymphoid hematopoietic system; tumor