胎元饮改善气血虚弱型先兆流产患者免疫机制探讨
| 作者: |
1张慧雯,
1乔成平
1 南京医科大学附属妇产医院(南京市妇幼保健院)中医科，南京 210004 |
| 通讯: |
乔成平
Email: 577389202@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.08.022 |
| 基金: | 南京医科大学科技发展基金面上项目(2016NJMU116)。 |
摘要
目的：探讨中药胎元饮对气血虚弱型先兆流产患者的疗效及其对免疫功能的影响。方法：选取44例气血虚弱型先兆流产患者，分别在入院时、胎元饮中药治疗1周后及2周后收集清晨空腹外周血，采用ELISA法检测相关免疫因子(IL-2，IL-10，IFN-γ，TGF-β1)，并对其症状进行评估，计算中医症候积分数。在治疗2周后，进行中医症候疗效评定，计算胎元饮治疗的有效率。结果：胎元饮中药治疗1周、2周后患者体内IL-2，IFN-γ因子水平显著降低，IL-10，TGF-β1因子水平显著升高(P<0.01)；与治疗前相比，饮用胎元饮中药治疗1周、2周后的症候积分显著下降(P<0.01)；饮用胎元饮中药治疗2周后的有效率可达98%。结论：胎元饮可能通过调节气血虚弱型先兆流产患者外周血IL-2，IFN-γ，IL-10及TGF-β1的表达，发挥治疗作用。
关键词：
胎元饮；气血虚弱型先兆流产；免疫机制
Immune mechanism on Taiyuanyin improving the prognosis of asthenia of Qi and blood type of threatened miscarriage patient
CorrespondingAuthor: QIAO Chengping Email: 577389202@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.08.022
Foundation: This work was supported by the Science and Technology Development Foundation Item of Nanjing Medical University, China (2016NJMU116).
Abstract
Objective: To explore the effect and immune mechanism of Taiyuanyin on asthenia of Qi and blood type of threatened miscarriage patient. Methods: A total of 44 patients diagnosed with asthenia of Qi and blood type of threatened miscarriage was included in this study. Fasting peripheral blood was collected when the patient at admittance, 1 and 2 weeks after the treatment, respectively. Immune factors (IL-2, IFN-γ, IL-10, TGF-β1) was detected by ELISA method. And at the same time, we assessed the change of symptoms and calculated the Chinese medicine symptom integral number on each patient. TCM syndrome effect was assessed to calculated the efficiency of Taiyuanyin after 2 weeks treatment. Results: Compared with patient at admittance, the level of IL-2, IFN-γ was significantly decreased and the level of IL-10, TGF-β1 was significantly increased in fasting peripheral blood at 1 and 2 weeks after the treatment. Compared with patient at admittance, TCM syndrome score was also significantly decreased at 1 and 2 weeks after the treatment. The efficiency of Taiyuanyin can reach 98%. Conclusion: Taiyuanyin regulated the level of IL-2, IFN-γ, IL-10, and TGF-β1 in peripheral blood to improve prognosis of asthenia of Qi and blood type of threatened miscarriage patient.
Keywords：
Taiyuanyin; asthenia of Qi and blood type of threatened abortion; immunologic mechanism