Objective: To observe the therapeutic effect of maggot debridement therapy combined with endovascular angioplasty in the treatment of diabetic foot. Methods: We collected patients with ischemic diabetic foot ulcers in Department of Endocrinology in The 454th Hospital of PLA from January 2013 to December 2015. The peripheral vascular disease was assessed by ankle-brachial index (ABI) and multi-slice spiral CT angiography. Wagner grading system was used to assess the wound grade. The patients were randomly divided into 2 groups: the experiment group received either maggot debridement therapy (MDT) or percutaneous transluminal angioplasty (PTA), while the control group received only PTA. Results: All patients who were with pain, cold, intermittent claudication had different degrees of improvement after surgery, and ABI increased significantly (P<0.05); patient who were treated with MDT, wound healing time was significantly shortened (P<0.05). Conclusion: PTA was an effective method for the treatment of ischemic diseases of the lower extremities. MDT combined with PTA could significantly shorten the healing time of diabetic foot wounds.