62例结直肠癌肝转移患者术后复发时间的风险因素
| 作者: |
1宋锦添,
1陈奕贵,
1杨建伟,
2许春伟,
1蔡雄超,
1郑亮,
1吴光锋,
1汤忠秀,
1张娟
1 福建医科大学附属肿瘤医院消化道肿瘤内科，福州 350014 2 福建医科大学附属肿瘤医院病理科，福州 350014 |
| 通讯: |
陈奕贵
Email: 1141554200@qq.com 杨建伟 Email: 1148534431@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.08.009 |
| 基金: | 国家临床重点专科建设项目(2013)。 |
摘要
目的：研究影响结直肠癌肝转移(colon rectal liver metastases，CRLM)术后复发时间的相关风险因素。方法：回顾性收集62例经原发灶切除及肝转移灶局部治疗的CRLM患者临床病理特征、分子特征、治疗方式和预后信息，分析以上因素对术后复发时间(recurrence-free survival，RFS)的影响。结果：单因素分析显示术前接受治疗、术前接受多学科讨论、BRAF基因野生型对比术前未接受治疗、未进行术前多学科讨论及BRAF基因突变型对患者RFS有统计学意义(P<0.05)；多因素分析发现仅术前癌胚抗原(carcino embryonic antigen，CEA)水平(P<0.001)、术前多学科讨论(P=0.004)是影响RFS的独立因素。结论：肠癌肝转移术前CEA水平和术前多学科讨论是术后RFS的独立预后因素。
关键词：
结直肠癌肝转移；术后复发时间；癌胚抗原；多学科团队
Prognostic risk factors of postoperative recurrence-free survival in 62 patients with colorectal cancer liver metastasis
CorrespondingAuthor: CHEN Yigui Email: 1141554200@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.08.009
Foundation: This work was supported by the National Clinical Key Specialty Construction Program, China (2013).
Abstract
Objective: To determine the prognostic risk factors on progression-free survival of colon rectal liver metastases (CRLM) undergoing surgical treatment. Methods: The clinicopathological characteristics, genetic factors and treatment method of 62 CRLM cases undergoing resection of primary tumor and local treatment of liver metastases were collected retrospectively. The relationship between these factors and postoperative recurrence-free survival (RFS) were investigated. Results: Univariate analysis showed that preoperative carcino embryonic antigen (CEA) level and tumor pathological type, number of liver metastases, primary tumor location, preoperative treatment, multidisciplinary team (MDT), BRAF status was statistically significant associated with RFS (P<0.05). Multivariate analysis showed that only preoperative CEA level (P<0.001) and MDT (P=0.004) were independent factors that affected RFS. Conclusion: Preoperative CEA level and MDT are independent prognostic factors of RFS for CRLM.
Keywords：
colon rectal liver metastases; recurrence-free survival; carcino embryonic antigen; multidisciplinary team