文章摘要

3 例卵巢原发性类癌临床病理观察

作者: 1赵莉莉, 1庞有成, 1陶陵, 1赵凯东, 1谭新宇
1 北京丰台医院病理科,北京 100070
通讯: 赵莉莉 Email: zll2004@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2018.07.036

摘要

分析3例卵巢原发性类癌的临床及病理组织学特征和免疫表型特点,并复习相关文献。3例患者发 病年龄分别为61岁,34岁和73岁,病例1查体时发现卵巢实性肿物,病例2剖腹产时发现卵巢囊实 性肿物,病例3因高血压、冠心病入院治疗,行B超检查发现卵巢囊实性肿物。3例组织学类型分别 为梁状型,梁状型混合有岛状,卵巢成熟性囊性畸胎瘤合并甲状腺肿类癌。肿瘤细胞免疫表型: 3例Syn(+);2例CgA(+);3例TTF-1(−);CDX2均(+)。卵巢原发性类癌属于低级别神经内分泌肿 瘤,具有低度恶性,预后良好。诊断中应首先排除转移性类癌,并与粒层细胞瘤、支持细胞瘤、 卵巢甲状腺肿、卵巢甲状腺乳头状癌及卵巢甲状腺髓样癌相鉴别。
关键词: 卵巢肿瘤;类癌;甲状腺肿类癌;免疫组织化学

Clinicopathological observation of three cases of primary ovary carcinoid

Authors: 1ZHAO Lili, 1PANG Youcheng, 1TAO Ling, 1ZHAO Kaidong, 1TAN Xinyu
1 Department of Pathology, Beijing Fengtai Hospital, Beijing 100070, China

CorrespondingAuthor: ZHAO Lili Email: zll2004@aliyun.com

DOI: 10.3978/j.issn.2095-6959.2018.07.036

Abstract

The clinical and histological and immunohistochemical characteristics were observed and analyzed. And the relevant literature of 3 cases of primary ovary carcinoid was reviewed. The onset age was 61, 34, and 73 years old respectively. Two patients mainly presented as solid or cystic-solid mass of ovary when made a physical examination and 1 patient was found to have a cystic-solid mass of ovary during caesarean section. The histological types were trabecular type, mainly trabecular type mixed with insular type, and strumal carcinoid with mature teratoma of ovary. Immunohistochemical staining results showed that 3 cases were positive for synaptophysin and CDX2, 2 cases were positive for chromogranin A, and 3 cases were negative for TTF-1. Thyroid area of strumal carcinoid was positive for TTF-1 and thyroglobulin. Primary ovary carcinoid belongs to low-grade neuroendocrine tumors, which has low potential malignancy and good prognosis. It should be differentiated from metastatic carcinoid, granulosa cell tumor, sertoli cell tumor, and thyroid papillary carcinoma of ovary and medullary thyroid carcinoma struma ovarii.
Keywords: ovary tumor; carcinoid; strumal carcinoid; immunohistochemistry

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