MiR-215 与肿瘤关系的研究进展
| 作者: |
1张兵,
1李高峰
1 昆明医科大学第三附属医院胸外二科，昆明 650118 |
| 通讯: |
李高峰
Email: ligaofenghl@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.07.034 |
| 基金: | 国家自然科学基金(81460356)。 |
摘要
MiR-215是miRNAs中的重要成员之一，在多种肿瘤中异常表达，既能发挥促癌作用，也能发挥抑 癌作用。MiR-215通过调节靶基因的表达，参与调控肿瘤细胞增殖、转移、凋亡和耐药等过程，其 表达水平与肿瘤的发生、发展和预后密切相关。因此miR-215有望成为肿瘤治疗的一个新型靶点。
关键词：
miR-215；靶基因；肿瘤；癌基因；抑癌基因
Research progress in miR-215 in tumors
CorrespondingAuthor: LI Gaofeng Email: ligaofenghl@126.com
DOI: 10.3978/j.issn.2095-6959.2018.07.034
Foundation: This work was supported by the National Natural Science Foundation of China (81460356).
Abstract
MiR-215 is one of the key members of miRNAs, which expresses abnormally in a variety of tumors and plays the role of oncogene and tumor suppressor genes. MiR-215 is involved in regulating the tumor cell proliferation, metastasis, apoptosis and drug resistance by controlling the expression of the target genes, so that its expression level is closely related to tumor formation, development and prognosis. Thus, miR-215 is expected to be a novel target for tumor therapy.
Keywords：
miR-215; target gene; tumor; oncogene; tumor suppressor gene