肠道病毒引起胰岛β 细胞损伤的分子机制
| 作者: |
1潘海东,
2刘启亮,
1郑天鹏
1 桂林医学院 第二附属医院内分泌科，广西 桂林 541199 2 桂林医学院 生物技术学院，广西 桂林 541199 |
| 通讯: |
郑天鹏
Email: 95623892@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.07.033 |
| 基金: | 广西高校中青年教师基础能力提升项目(2017KY0488)。 |
摘要
1型糖尿病(type 1 diabetes mellitus，T1DM)是儿童和青少年中的一种常见慢性疾病，其主要特点是 胰岛β细胞显著减少，胰岛素分泌不足，血糖升高，且容易引起一系列并发症，需要终身注射外源 性胰岛素。在T1DM患者的胰岛细胞和血液中发现肠道病毒(enteroviruses，EV)及其相关蛋白质， 提示EV感染与β细胞损伤密切相关，特别是柯萨奇B组4型病毒(coxsackievirus B4，CVB4)。目前， 主流观点认为EV引起自身免疫反应导致胰岛β细胞死亡而致T1DM的发生，但EV引起胰岛β细胞损 伤和死亡的机制尚未明确。
关键词：
1型糖尿病；肠道病毒；自身免疫反应
Molecular mechanism of pancreatic β-cell damage induced by enterovirus infection
CorrespondingAuthor: ZHENG Tianpeng Email: 95623892@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.07.033
Foundation: This work was supported by the Fundamental Ability Improving Program for Young and Mid-aged University Teachers in Guangxi, China (2017KY0488).
Abstract
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood and adolescents, the main feature of which is the destruction of the insulin-producing pancreatic beta cells and the subsequent loss of insulin, and the accumulation of glucose in the blood; resulting in the late development of vascular and neuropathic complication, and consequently, patients with T1DM remain insulin-dependent for their lifespan. Enteroviral RNA and proteins has been detected in the blood of T1DM patients and serological analysis confirmed a link between enteroviral infection and T1DM, particularly for the coxsackievirus B4 (CVB4) serotype. It’s unknown, however, that potential mechanisms by which enteroviruses could contribute to the specific destruction of pancreatic β cells in T1DM.
Keywords：
type 1 diabetes; enterovirus; autoimmunity