文章摘要

II 型糖尿病并发抑郁症与NLRP3炎症小体关系的研究进展

作者: 1许拓, 2奉水东, 3高湖广, 1何剑琴, 1凌宏艳
1 南华大学生理学教研室，湖南 衡阳 421001
2 南华大学社会医学与卫生事业管理学教研室，湖南 衡阳 421001
3 南华大学2017级卓越医生1班，湖南 衡阳 421001
通讯: 凌宏艳 Email: linghongyan0203@126.com
DOI: 10.3978/j.issn.2095-6959.2018.07.032
基金: ：湖南省自然科学基金(2018JJ2347)；湖南省教育厅基金(16C1411)；衡阳市科技局基金(2016KJ64)。

摘要

II型糖尿病并发抑郁症是自杀率最高的慢性并发症之一。NLRP3炎症小体是先天免疫系统中的胞 内传感器，能够介导下游caspase-1及IL-1β等炎症因子成熟与分泌。研究发现NLRP3炎症小体在II 型糖尿病患者中持续激活，同时NLRP3炎症小体的激活在抑郁症发病中扮演重要角色，因此推测 NLRP3炎症小体的激活可能介导了II型糖尿病并发抑郁症。
关键词： II型糖尿病；抑郁症；NLRP3炎症小体；IL-1β

Research progress in type 2 diabetes with depression and NLRP3 inflammasome

Authors: 1XU Tuo, 2FENG Shuidong, 3GAO Huguang, 1HE Jianqin, 1LING Hongyan
1 Department of Physiology, University of South China, Hengyang Hunan 421001, China
2 Department of Social Medicine and Health Service Management, University of South China, Hengyang Hunan 421001, China
3 Class 1 of 2017 Excellent Doctor, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: LING Hongyan Email: linghongyan0203@126.com

DOI: 10.3978/j.issn.2095-6959.2018.07.032

Foundation: This work was supported by the Natural Science Foundation of Hunan Province (2018JJ2347), the Foundation of Educational Bureau of Hunan Province (16C1411)

Abstract

Type 2 diabetes mellitus with depression is an important cause of suicide in patients. NLRP3 inflammasome is an intracellular sensor in the innate immune system which can mediate the maturation and secretion of caspase-1/ IL-1β and other inflammatory factors. Recent studies have found that NLRP3 inflammasomes are continuously activated in patients with type 2 diabetes, and the activation of NLRP3 inflammasome plays an important role in the pathogenesis of depression, so we speculate that activation of the NLRP3 inflammasome may mediate the process of type 2 diabetes with depression.
Keywords： type 2 diabetes; depression; NLRP3 inflammasome; IL-1β

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