Notch信号转导通路在骨发育与骨重建中的作用
| 作者: |
1,2,3,4朱佳瑜,
1,3,4周后德
1 中南大学湘雅二医院代谢内分泌科，长沙 410011 2 新疆医科大学第一附属医院内分泌科，乌鲁木齐 830054 3 中南大学湘雅二医院代谢性骨病学湖南省重点实验室，长沙 410011 4 中南大学湘雅二医院国家代谢性疾病临床医学研究中心，长沙 410011 |
| 通讯: |
周后德
Email: houdezhou@csu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2018.05.035 |
| 基金: | 国家自然科学基金(81770880)；代谢性骨病学湖南省重点实验室(2017TP1006)；湖南省科学技术协会(2017TJ-Q14)。 |
摘要
Notch信号转导通路是一广泛存在且高度保守的信号通路，参与细胞的增殖、分化和凋亡，并在胚胎发育和组织更新中起重要作用。骨重建的过程包括骨形成以及骨吸收。源于间充质干细胞的成骨细胞形成骨，以及单核细胞的破骨细胞吸收骨，二者协同在骨发育和骨重建过程中发挥重要作用。本文重点阐述Notch信号转导通路促进骨发育，调节基质干细胞的分化定型，以及调控成骨、破骨分化与功能，进而影响骨重建。
关键词：
Notch信号转导通路；骨发育；骨重建
Role of Notch signal pathway on bone development and remodeling
CorrespondingAuthor: ZHOU Houde Email: houdezhou@csu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2018.05.035
Foundation: This work was supported by the National Natural Science Foundation (81770880), the Hunan Provincial Key Laboratory of Metabolic Bone Diseases (2017TP1006)
Abstract
Notch signal pathway is widespread and highly conservative, which is involved in cell proliferation, differentiation and apoptosis, and plays important roles in embryonic development and tissue renewal. The process of bone remodeling includes bone formation and bone resorption. Osteoblasts derived from mesenchymal stem cells form bone, and osteoclasts derived from monocytes absorb bone, both play important roles in bone development and bone remodeling. Notch signal transduction pathway promotes bone development and determines the commitment of the bone marrow stem cells, as well as impacts bone reconstruction by regulating differentiation and function of osteoblast and osteoclast.
Keywords：
Notch signal pathway; bone development; bone remodeling