文章摘要

Notch信号通路在呼吸道疾病及细胞免疫中的研究进展

作者: 1郭乐, 1,2胡瑞成, 1,2朱黎明, 1,3蒋永亮, 2李洁, 1,4戴爱国
1 南华大学临床医学系，湖南 衡阳 421001
2 湖南省人民医院马王堆院区呼吸内科，长沙 410016
3 湖南省人民医院天心阁院区呼吸内科，长沙 410005
4 长沙医学院呼吸疾病研究所，长沙 410219
通讯: 戴爱国 Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2018.05.034

摘要

Notch信号通路是一个在进化过程中高度保守的信号通路，参与大部分无脊椎动物和脊椎动物的配体分化发育，该信号通路是通过细胞之间的直接接触发挥作用，调控机体的细胞识别、凋亡、增殖和分化。近年来，Notch信号通路与许多疾病的发生发展关系已成为研究热点之一。
关键词： Notch信号通路；呼吸道疾病；细胞免疫；进展

Research progress on Notch signaling pathway in respiratory diseases and cellular immunity

Authors: 1GUO Le, 1,2HU Ruicheng, 1,2ZHU Liming, 1,3JIANG Yongliang, 2LI Jie, 1,4DAI Aiguo
1 Department of Clinical Medicine, University of South China, Hengyang Hunan 421001, China
2 Department of Respiratory Medicine, Mawangdui District, Hunan People’s Hospital, Changsha 410016, China
3 Department of Respiratory Medicine, Tianxin’ge District, Hunan People’s Hospital, Changsha 410005, China
4 Institute of Respiratory Diseases, Changsha Medical University, Changsha 410219, China

CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com

DOI: 10.3978/j.issn.2095-6959.2018.05.034

Abstract

Notch signal pathway is the one which is highly conservative in evolution, it involves in ligand differentiation and development of most invertebrates and vertebrates. Notch signal pathway works through direct contact between cells, which regulates and controls the recognition, apoptosis, proliferation and differentiation of many cell bodies. In recent years, Notch signal pathway is related to the occurrence and development of many diseases, which becomes one of the research hotspots.
Keywords： Notch signaling pathway; respiratory disease; cellular immunity; progress

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