Objective: To explore the application value of nursing intervention program based on cross theoretical model in patients after total hip replacement. Methods: Totally 111 patients after total hip replacement were divided into a control group and an observation group by the patient’s admission time. Fifty-five patients from January 2015 to June 2015 were selected as control group, and routine health education and nursing intervention were adopted. Fifty-six patients from January 2016 to June 2016 were selected as the observation group, the nursing intervention program based on the cross theoretical model was adopted to intervene. The rehabilitation exercise compliance questionnaire, the Harris hip function assessment scale and the functional independence measure (FIM) were used to evaluate the patients before intervention and 1 months, 3 months and 6 months after the intervention. Results: The rehabilitation training compliance score, hip joint function score and independent motor function scores of the observation group after 1, 3 and 6 months were significantly better than the control group. The group effects, time effects and the interaction effects between the two groups were statistically significant (P<0.01). Conclusion: The nursing intervention program based on the cross theoretical model can effectively improve the rehabilitation training compliance of patients after total hip replacement, and improve the rehabilitation exercise effect.