Objective: To investigate the characteristics of coagulation indexes in patients with colorectal cancer and its clinical significance. Methods: Data of coagulation index collected from 153 colorectal cancer patients were statistically analyzed. Results: Among 153 cases of colorectal cancer, 113 cases (73.86%) of patients were with blood hypercoagulability, in which 98 cases (86.72%) with D-D increased, 58 cases (51.33%) with PLT elevated, 34 cases (30.09%) with FIB elevated, 6 cases (5.31%) with APTT shortened, 4 cases (3.54%) with PT shortened; 47 cases (41.59%) with two abnormal indexes, in which 32 cases (28.32%) with PLT, D-D increased; 18 cases (15.66%) with three or more abnormal indexes, in which 15 cases (13.27%) with PLT, FIB and D-D increased. PLT, FIB levels in the ≥60 years group were higher than those in the <60 years group (P<0.05); there was no statistically significant difference in gender (P>0.05). PLT, FIB and D-D levels in the ECOG score ≥2 group were higher than than those in the ECOG score <2 group (P<0.05); D-D levels in both smoking and drinking group were higher than that in the non-smoking and non-drinking group (P<0.01); PLT, D-D levels in the no merger diseases group were lower than that in the merger group (P<0.01); the differences in FIB, PLT, D-D among grade I–II, III and IV were all significantly different (P<0.01). Age ≥60 years, ECOG score ≥2, smoking and drinking, combined diseases and metastasis of colorectal cancer were risk factors of HCS (P<0.05). Conclusion: The colorectal cancer patients’ blood is often hypercoagulable, in which elevated PLT, FIB and D-D were the main abnormal coagulation indexes. Age ≥60 years, ECOG score ≥2, especially smoking and drinking, combined diseases and metastasis of colorectal cancer, are risk factors of hypercoagulability.