高尿酸血症与慢性肾脏病的研究进展
| 作者: |
1李文莹,
1解汝娟
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150001 |
| 通讯: |
李文莹
Email: 372968953@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.03.025 |
| 基金: | 国家自然科学基金(81670659)。 |
摘要
高尿酸血症(hyperuricemia，HUA)逐年升高的发病率使其受到人们广泛的关注。HUA不仅是痛风的主要原因，它还与肾、心血管等多系统性疾病的发病及发展密切相关。本文简要介绍血清尿酸(serum uric acid，SUA)的代谢及抗氧化剂的生理学作用、HUA致肾损伤的机制。
关键词：
高尿酸血症；慢性肾脏病；损伤机制
Research progress in hyperuricemia and chronic kidney disease
CorrespondingAuthor: LI Wenying Email: 372968953@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.03.025
Foundation: This work was supported by the National Natural Science Foundation of China (81670659).
Abstract
There is great concern for the increasing incidence of hyperuricemia (HUA). HUA is not only the main cause of gout, but also closely related to many systemic diseases and their development such as kidney diseases and cardiovascular diseases. This article briefly describes the metabolism of serum uric acid (SUA) and the biological effects of antioxidants, as well as the mechanism of kidney injury induced by HUA.
Keywords：
hyperuricemia; chronic kidney disease; injury mechanism