Objective: To study the therapeutic effects of ozone liquid in the treatment of skin burst patients with dermatomyositis. Methods: Fifty-six patients with dermatomyositis hospitalized in the Department of Rheumatology of Xiangya Hospital of Central South University from April 2016 to September 2017 were selected and randomly divided into an experiment group (n=30) and a control group (n=26). The control group used iodine complex disinfection with stroke-physiological saline solution cleaned and then covered by the Nano silver gel(30 min/times, 2 times/d)for treatment of DM patients with skin ulceration; the experiment group treated though hydropathic compress or soak with medical ozone liquid application for 20 min,and then covered by the Nano silver gel (30 min/times, 2 times /d). Results: The healing effective rate of the experiment group (83.33%) was higher than that of control group (61.53%); the comfort score of the experimental group before and after the treatment was 61.63±9.14 and 76.37±8.08, while the control group was 59.63±7.23 and 66.12±6.12; the incidence of anxiety was 57.69% in the control group, while only 36.66% in the experiment group, the differences were statistically significant between the two groups (P<0.05). Conclusion: External application of ozone liquid plus Nano silver gel is superior to iodine complex plus Nano silver gel dressing change on skin ulceration, which can be a reference for nursing of skin ulceration in DM patients.