维生素D与肾病综合征的相关性
| 作者: |
1冯爱静,
1吴红赤
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150001 |
| 通讯: |
吴红赤
Email: 2462684173@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.02.032 |
| 基金: | 黑龙江省教育厅科学技术研究项目(12541264)。 |
摘要
维生素D是一种人体必需的脂溶性维生素，也是一种类固醇激素，通过其活性形式作用于维生素D受体发挥作用。除经典的调节钙、磷代谢的作用外，近期研究发现维生素D还有调节免疫功能、抑制炎症反应、抑制细胞的增殖、分化等非经典作用。肾病综合征(nephrotic syndrome，NS)是一种由免疫紊乱引起的常见的肾脏疾病，其病理生理的改变及糖皮质激素的应用可影响维生素D的代谢。因此维生素D水平与NS具有密切相关性。
关键词：
维生素D；维生素D受体；肾病综合征
Correlation between vitamin D and nephrotic syndrome
CorrespondingAuthor: WU Hongchi Email: 2462684173@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.02.032
Foundation: This work was supported by Science and Technology Research Project of Heilongjiang Department of Education, China (12541264).
Abstract
Vitamin D is a kind of essential fat-soluble vitamins in human body, as well as a kind of steroid hormone. Vitamin D plays a role through its active form acting on a vitamin D receptor. In addition to the role in the regulation of calcium and phosphorus metabolism, recent studies have found that vitamin D also regulate immune function, inhibit inflammatory response, inhibit cell proliferation, differentiation and other non-classical role. Nephrotic syndrome (NS) is a common kidney disease caused by immune disorders. The changes of its pathophysiology and the use of glucocorticoids can affect the metabolism of vitamin D. Vitamin D levels are closely related to NS.
Keywords：
vitamin D; vitamin D receptor; nephrotic syndrome