P53蛋白在葡萄胎中表达的Meta分析
| 作者: |
1张蕾,
1赵丹丹,
1李家平,
1朱园园,
1沈乾坤,
1何涛
1 河南科技大学临床医学院，河南科技大学第一附属医院妇产科，河南 洛阳 471003 |
| 通讯: |
何涛
Email: taohfk@163.com |
摘要
目的：系统评价P53蛋白在葡萄胎(hydatidiform mole，HM)中的表达与鉴别诊断作用。方法：检索Pubmed，Medline，Embase，CNKI，Wanfang Data，VIP及CBM数据库，并追溯相关参考文献。选择RevMan 5.3版本进行Meta分析，采用Begg’s，Egger’s分析纳入文献的发表偏倚。结果：共纳入18个研究，包括完全性葡萄胎(complete hydatidiform mole，CHM)436例，部分性葡萄胎(partial hydatidiform mole，PHM)369例和水肿性流产(hydropic abortus，HA)220例。Meta分析结果示CHM组P53表达明显高于PHM组(OR=2.84，95%CI 2.00~4.04，P<0.001)；亚组分析结果示在欧洲人中，CHM组与PHM组中P53表达无统计学意义(OR=0.55，95%CI 0.16~1.85，P=0.33)；在亚洲人中，CHM组P53表达明显高于PHM组(OR=3.36，95%CI 2.31~4.88，P<0.001)；CHM与PHM组的P53阳性率均明显高于HA组(OR=32.15，95%CI 18.97~54.49，P<0.001；OR=13.11，95%CI 8.21~20.93，P<0.001)。结论：P53蛋白的高表达可能在HM的发生发展中起重要作用。
关键词：
葡萄胎；P53蛋白；Meta分析；病例-对照研究
Expression of P53 protein in hydatidiform mole: A Meta-analysis
CorrespondingAuthor: HE Tao Email: taohfk@163.com
Abstract
Objective: To systematically review the expression of P53 protein in hydatidiform mole and its differential diagnosis. Methods: Relevant literature sources were searched using databases from the inception to May 1, 2017 including Pubmed, Medline, Embase, CNKI, Wanfang Data, VIP and CBM, and the related references were traced. RevMan 5.3 was used for our Meta-analysis, and Begg’s and Egger’s were used to analyze possible publication bias. Results: A total of 18 studies involving 436 complete hydatidiform mole (CHM), 369 partial hydatidiform mole (PHM) and 220 hydropic abortus (HA) were included. The expression of P53 in CHM group was significantly higher than that of PHM group (OR =2.84, 95% CI 2.00–4.04, P<0.001); but the subgroup analysis showed: there was no significant expression between CHM group and PHM group in Europe (OR =0.55, 95% CI 0.16–1.85, P=0.33); in Asians, the expression of P53 in CHM group was significantly higher than that of PHM group (OR =3.36, 95% CI 2.31–4.88, P<0.001); the positive rate of P53 in CHM and PHM group were significantly higher than those of hydropic abortion group (OR =32.15, 95% CI 18.97–54.49, P<0.001; OR =13.11, 95% CI 8.21–20.93, P<0.001). Conclusion: Current evidence shows that the high expression of P53 may play an important role in the genesis and development of hydatidiform mole, which can provide a reference for the early diagnosis and treatment of hydatidiform mole.
Keywords：
hydatidiform mole; P53 protein; Meta-analysis; case-control study