文章摘要

创伤性颅脑损伤患者中降钙素原、CRP及D-二聚体的 临床检测意义

作者: 1缪惠锴, 2王嘉妮, 2刘璐, 2肖立
1 南京医科大学附属无锡第二医院检验科,江苏 无锡 214002
2 解放军第101医院检验科,江苏 无锡 214044
通讯: 缪惠锴 Email: miaohuikai1989@163.com
DOI: 10.3978/j.issn.2095-6959.2018.01.007

摘要

目的:研究创伤性颅脑损伤(traumatic brain injury,TBI)患者中降钙素原(procalcitonin,PCT),CRP,D-二聚体水平与患者病情程度及临床预后中的价值。方法:分析2014年1月至2016年12月接受治疗的250例TBI患者,采用格拉斯哥昏迷评分法(Glasgow Coma Scale,GCS)评估病情,电化学发光法及免疫散射比浊法检测患者血清中PCT,CRP和D-二聚体水平,分析其与患者病情的相关性,Cox回归模型探讨与患者死亡的关系。结果:TBI患者中PCT,CRP,D-二聚体水平随着病变的严重程度增加明显升高,差异具有统计学意义(P<0.05);存活组GCS评分显著高于死亡组(P<0.01),而PCT,CRP及D-二聚体水平均显著低于死亡组(P<0.01);多因素分析提示GCS评分,PCT,CRP以及D-二聚体是TBI患者死亡的独立因素;PCT,CRP,D-二聚体水平与患者入院时GCS评分存在负相关,相关系数分别为–0.23,–0.32,–0.42(均P<0.05)。结论:PCT,CRP,D-二聚体水平与TBI患者的损伤程度及预后具有明显相关性。
关键词: 降钙素原;CRP;D-二聚体;创伤性颅脑损伤

Clinical detection significance of procalcitonin, CRP and D-dimer in traumatic brain injury patients

Authors: 1MIAO Huikai, 2WANG Jiani, 2LIU Lu, 2XIAO Li
1 Department of Clinical Laboratory, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi Jiangsu 214002, China
2 Department of Clinical Laboratory, The 101st Hospital of PLA, Wuxi Jiangsu 214044, China

CorrespondingAuthor: MIAO Huikai Email: miaohuikai1989@163.com

DOI: 10.3978/j.issn.2095-6959.2018.01.007

Abstract

Objective: To analyze the effects of procalcitonin (PCT), CRP, D-dimer on the severity and clinical prognosis of patients with traumatic brain injury (TBI). Methods: A total of 250 TBI patients were recruited from January 2014 to December 2016, and the disease severity was assessed by Glasgow Coma Scale (GCS) score. Levels of PCT, CRP and D-dimer were detected and their co-relationship with patient’s condition and death rate were investigated, and the Cox review model was used to explore the relationship with the patient’s death. Results: Level of PCT, CRP and D-dimer in TBI patients increased significantly with the severity of the lesion; the level of GCS score of patients in the survival group elevated significantly when compared with that in the death group, whereas the levels of PCT, CRP and D-dimer in the survival group decreased significantly. Multivariate analysis indicated that PCT, CRP, D-dimer and GCS score were independent risk factors for death in TBI patients. The levels of PCT, CRP and D-dimer were positive with GCS (r=‒0.23, ‒0.32, ‒0.42; P<0.05). Conclusion: Level of PCT, CRP and D-dimer closely associated with the severity and prognosis of TBI patients.
Keywords: procalcitonin; C reaction protein; D-dimer; traumatic brain injury

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