Objective: To evaluate the effect of continuing care on WeChat in prevention of peripherally inserted venous central catheter (PICC) in patients with cancer. Methods: Electronic databases including periodical full text database of science and technology in China, periodical full text database in China, Wanfang Database, Weipu Database, PubMed, and Web of Science were searched and two independent reviewers identified relevant parallel trials, assessed trial quality and extracted data. Review Manager (version 5.3) was applied to conduct a meta-analysis of the extracted data to obtain the value of odds ratio (OR) and their 95% confidence interval (CI). The checking of the publication bias was conducted according to the number of studies. Results: There were six studies having altogether 678 cancer patients with PICC included. There was significant difference on the incidence of catheter extrusion (OR=0.25, 95% CI 0.08–0.77, P<0.001), catheter-related infection (OR=0.25, 95% CI 0.11–0.59, P<0.001), phlebophlogosis (OR=0.23, 95% CI 0.06–0.91, P<0.001), skin allergy (OR=0.27, 95% CI 0.08–0.86, P<0.001), and thrombogenesis (OR=0.28, 95% CI 0.14–0.56, P<0.001), in the treatment group compared to control group. Conclusion: The existing data supported that continuing nursing care can significantly reduce the occurrence rate of complication of PICC in cancer patients.