Objective: To evaluate the effectiveness of multi-professional collaborative management in shortening the early treatment time of severe trauma patients. Methods: Eighty-eight cases of patients with severe trauma from February 2016 to April 2017 in the emergency department of our hospital were selected as the subjects. Among them, 44 cases from February 2016 to September 2016 were set as the control group, which received the conventional hospital treatment process; 44 cases from October 2016 to April 2016 were selected as the observation group, which received the professional cooperative treatment comparison process. The admission to definite diagnosis time, admission to operation time, the rescue success rate and complication rate of the two groups of patients were compared. Results: The admission to definite diagnosis time and admission to operation time in the observation group were significantly shorter than the control group, the rescue success rate of the observation group was significantly higher than that in the control group (86.36% vs 68.18%), the complication rate was significantly lower than that in the control group (22.73% vs 43.18%). Conclusion: The implementation of multidisciplinary collaborative process can effectively shorten the time of diagnosis and surgical treatment in patients with severe trauma, improve the success rate of rescue, it is worthy of further promotion in clinical.