Objective: To investigate the relationship between serum ferritins (SF), cortisol (Cor), homocysteine (Hcy) and prognosis of patients with hypertensive intracerebral hemorrhage. Methods: A total of 96 patients with hypertensive intracerebral hemorrhage treated in the First Affiliated Hospital of Xinxiang Medical University from March 2015 to July 2016 were enrolled as the observation group and 90 healthy peoples were enrolled as the control group. The levels of SF, Cor and Hcy were compared in two groups. The differentiation of SF, Cor and Hcy levels were observed in patient with different degree of nerve injury and different prognosis. The differences of clinical feature in patients with different prognosis were studied. Results: The levels of SF, Cor and Hcy in observation group were significantly higher than those in control group (P<0.05). The levels of SF, Cor and Hcy in patents with hypertensive intracerebral hemorrhage were significantly increased as nerve injury increased progressively (P<0.05). The levels of SF, Cor and Hcy in good prognosis group were significantly lower than those in poor prognosis group (P<0.05). The rate of age younger than 60, bleeding volume less than 30mL and hemorrhage not breaking into ventricle in good prognosis group were significantly higher than those in poor prognosis group (P<0.05). In patients with hypertensive intracerebral hemorrhage, SF, Cor, Hcy, ages, bleeding volume, hemorrhage not breaking into ventricle were independent prognostic risk factors (P<0.05). Conclusion: SF, Cor and Hcy may be involved in the occurrence and development of hypertensive intracerebral hemorrhage. The levels of those indexes are closely correlated with the injury of nerve degree and prognosis.