急性放射性口腔黏膜炎患者血液中T细胞亚群的变化
| 作者: |
1刘珊,
1陆叶,
1沈红梅
1 云南省中西结合肿瘤临床研究中心，云南省肿瘤医院，昆明医科大学第三附属医院中西医结合科，昆明 650118 |
| 通讯: |
沈红梅
Email: lilyydfz@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.12.022 |
| 基金: | 云南省医疗卫生单位内设研究机构科研项目(2014NS036，2017NS182)；云南省教育厅科学研究基金(2016ZDX061)。 |
摘要
目的：探索鼻咽癌患者在放疗期间放射性口腔炎的严重程度、体力状况以及T细胞亚群的水平。方法：选择2015年12月至2016年12月于云南省肿瘤医院住院治疗、病理确诊为鼻咽鳞状细胞癌、首次接受根治性放疗的患者48例(脱落4例)，比较患者在放疗前、放疗第4周以及放疗后3个时期放射性口腔炎严重程度、体力状况及血液中T细胞亚群的水平。结果：随着放疗剂量的增加，患者放射性口腔炎严重程度呈上升趋势，KPS评分呈下降趋势，外周血中T细胞亚群水平呈下降趋势，差异具有统计学意义(P<0.01)。结论：放射线的计量累积可以使放射性口腔黏膜炎的严重程度逐渐加重，患者生活质量下降并破坏机体的免疫功能。
关键词：
急性放射性口腔黏膜炎；T细胞亚群；放疗
Change of T cell subset in acute radiation oral mucosa
CorrespondingAuthor: SHEN Hongmei Email: lilyydfz@126.com
DOI: 10.3978/j.issn.2095-6959.2017.12.022
Foundation: This work was supported by the Internal Research Institute Program of Medical and Health Organization in Yunnan Province (2014NS036, 2017NS182) and the Research Foundation of Yunnan Educational Committee (2016ZDX061)
Abstract
Objective: To explore the severity of acute radiation oral mucosa, KPS score, and the level of T cell subset in the saliva in patients with nasopharyngeal carcinoma. Methods: Forty-eight patients (4 dropped out), pathologically diagnosed as nasopharyngeal carcinoma, who underwent radiotherapy for the first time with (according to the TNM staging, M staging is M0) in our hospital from December 2015 to December 2016 were enrolled in the study. The severity of acute radiation oral mucosa, KPS score and the level of T cell subset in the saliva in patients were compared among early, middle and late stage of radiotherapy. Results: With the increasing of radiation dose, the severity of acute radiation oral mucosa increased, the KPS score decreased, and the level of T cell subset decreased, the differences were all statistically significant (P<0.01). Conclusion: Radiation accumulation can increase the severity of acute radiation oral mucosa inflammation, decrease patients’ quality of life, and destroy the patients’ immune function.
Keywords：
acute radiation oral mucosa; T cell subset; radiotherapy