膀胱癌组织中HSPC238的表达及其临床意义
| 作者: |
1卢志承,
1符志龙,
1陈世梁,
1吴文川
1 海南省人民医院病理科，海口 570311 |
| 通讯: |
卢志承
Email: 21243762@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.12.021 |
摘要
目的：检测膀胱癌患者肿瘤组织中HSPC238的改变，并探讨其相关的临床意义。方法：取海南省人民医院2016年1月至2017年7月收治的膀胱癌116例，取癌旁非肿瘤组织作为对照。使用荧光定量PCR检测HSPC238基因的表达。结果：膀胱癌组织中HSPC238为0.172±0.023，显著低于对照膀胱组织的0.304±0.051(P<0.01)。HSPC238在TNM临床III，IV期患者为0.137±0.017，显著低于I，II期患者的0.194±0.028(P<0.01)。HSPC238在浸润深度达到肌层的患者为0.161±0.021，显著低于未达到肌层的0.195±0.029(P<0.05)。HSPC238在中、低分化患者为0.156±0.021，显著低于高分化的0.205±0.037(P<0.05)。HSPC238在淋巴结有转移患者为0.147±0.016，显著低于无转移的0.181±0.022(P<0.05)。结论：膀胱癌组织中HSPC238基因低表达，其表达变化可能参与膀胱癌的发生、发展、侵袭和转移。
关键词：
膀胱癌；HSPC238基因；荧光定量-PCR
HSPC238 mRNA expression in bladder cancer and its clinical significance
CorrespondingAuthor: LU Zhicheng Email: 21243762@qq.com
DOI: 10.3978/j.issn.2095-6959.2017.12.021
Abstract
Objective: To detect HSPC238 mRNA expression in bladder cancer and explore its clinical significance. Methods: A total of 116 patients of bladder cancer were enrolled in this study. The non-cancerous tissues beside the tumor were taken as controls. Real-time PCR analysis was used to detect HSPC238 mRNA expression. Results: HSPC238 in bladder cancer tissue was 0.172±0.023, which was lower than that of 0.304±0.051 in control tissue (P<0.01). HSPC238 in III and IV stage group was 0.137±0.017, which was lower than that of 0.194±0.028 in I and II stage group (P<0.01). HSPC238 of patients with muscular layer infiltration was 0.161±0.021, which was lower than that of 0.195±0.029 in non-muscular layer infiltration patients (P<0.05). HSPC238 in median and low differentiation group was 0.156±0.021, which was lower than that of 0.205±0.037 in well differentiation group (P<0.05). HSPC238 in lymph node metastasis group was 0.147±0.016, which was lower than that of 0.181±0.022 in non-lymph node metastasis group (P<0.05). Conclusion: Low expression of HSPC238 was detected in bladder cancer, which was related to clinical stages, lymph node metastasis, and tumor differentiation of bladder cancer.
Keywords：
bladder cancer; HSPC238 gene; real-time PCR analysis