Objective: To study the effects of rehabilitation robot in children with hand-foot-mouth disease in convalescence and lower limb paralysis. Methods: A total of 60 children with hand-foot-mouth disease in convalescence and lower limb paralysis who were treated in the hospital during the period from March 2013 to March 2016 were selected as the study subjects and randomly divided into a control group and an observation group according to the order of treatment, 30 cases in each group. The control group was given routine rehabilitation training while the observation group was given lower limb rehabilitation robot assisted ambulation training on the basis of routine rehabilitation training. The lower limb muscle strength, balance ability, range of motion, gait parameters and lower limb motor ability were compared after 6 months between the two groups. Results: After 6 weeks of intervention, the grade of hip flexion muscle strength, the grade of knee extension muscle strength, Berg balance score (BBS), the hip range of motion, the knee range of motion, step length, walking speed, Fugl-Meyer assessment (FMA) of lower limb motor function in the observation group [3.08±0.62, 3.18±0.60, 50.36±7.92, 23.17°±3.45°, 26.39°±4.31°, (51.27±14.83) cm, (64.72±14.38) m/min, 23.14±5.39] were significantly higher than those in the control group [2.80±0.58, 2.85±0.63, 45.89±8.12, 20.65°±4.63°, 22.96°±4.74°, (44.65±12.91) cm, (58.01±12.46) m/min, 20.27±3.62] (all P<0.05). Conclusion: The use of rehabilitation robot assisted walking training can enhance the muscle strength of lower limbs, improve balance ability and joint range of motion, establish the correct walking pattern and promote the recovery of lower limb motor ability of children with hand-foot-mouth disease in convalescence and lower limb paralysis.