二叶式主动脉瓣基础与临床
| 作者: |
1蔡怀敏,
1王春生,
1孙晓宁
1 复旦大学附属中山医院心脏外科，上海 200032 |
| 通讯: |
孙晓宁
Email: sun.xiaoning@zs-hospital.sh.cn |
| DOI: | 10.3978/j.issn.2095-6959.5595 |
| 基金: | 上海市浦江人才计划 14PJD008 上海市自然科学基金 17ZR1432900 |
摘要
二叶式主动脉瓣(bicuspid aortic valve，BAV)是目前最常见的先天性心脏病，患病率预计为0.5%~2%，男性患者与女性患者的比例约为3:1。可以单独发生，也可以伴随其他的先天性心血管病。BAV患者常出现主动脉瓣返流、主动脉瓣狭窄、主动脉扩张、主动脉瘤、主动脉夹层、血栓和感染性心内膜炎等并发症。BAV的瓣膜可有正常的功能，也可产生钙化、狭窄或者关闭不全等功能紊乱。
关键词：
二叶式主动脉瓣
基因
并发症
主动脉扩张
Fundamental and clinical study of bicuspid aortic valve
CorrespondingAuthor: SUN Xiaoning Email: sun.xiaoning@zs-hospital.sh.cn
DOI: 10.3978/j.issn.2095-6959.5595
Abstract
Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect, occurring in 0.5%–2% of the general population. It is almost 3 times more common in males than females. BAV can occur alone. Moreover, BAV may be associated with other cardiovascular anomalies. Complications associated with BAV include aortic stenosis (AS) and regurgitation, aortic dilation and dissection, thrombus and infective endocarditis. This review summarizes current understanding of anatomy, genetics, and clinical aspects of BAV disease.
Keywords：
bicuspid aortic valve
gene
Complication
aortic dilation