文章摘要

基因检测在结肠癌预后中的临床应用

作者: 1孔令红, 2万智毅, 1刘晓刚
1 北京市垂杨柳医院病理科，北京 100022
2 中国农业大学生物学院农业生物技术国家重点实验室，北京 100193
通讯: 刘晓刚 Email: chinalark@163.com
DOI: 10.3978/j.issn.2095-6959.2017.10.034
基金: 北京市垂杨柳医院硕博基金 2015-02

摘要

准确预测II期结肠癌患者的术后复发风险对制定适合患者的治疗方案十分重要。然而，传统临床病理中的风险因素并不足以准确地评估患者的复发风险进而指导临床决定。随着基因组学技术的发展，越来越多的研究证实基因检测能提供更个体化更准确的预后信息。这些方法主要包括检测基因突变、基因表达及术后循环肿瘤DNA等3个方向。
关键词： 结肠癌 预后 基因突变 基因表达 循环肿瘤DNA

Clinical applications of gene test in colon cancer prognosis

Authors: 1KONG Linghong, 2WAN Zhiyi, 1LIU Xiaogang
1 Department of Pathology, Beijing Chuiyangliu Hospital, Beijing 100022
2 State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China

CorrespondingAuthor: LIU Xiaogang Email: chinalark@163.com

DOI: 10.3978/j.issn.2095-6959.2017.10.034

Abstract

Accurate prediction of recurrence risk is of vital importance for formulating suitable therapeutic regimen for patients who have had surgery for stage II colon cancer. However, conventional clinicopathological criteria are not accurate enough to evaluate the individual recurrence risk of patient. With the development of genomics, several gene assays have been confirmed to accurately assess the individual recurrence risk for colon cancer prognosis. These assays include detection of gene mutation, gene expression, and circulating tumor DNA (ctDNA).
Keywords： colon cancer Prognosis gene mutation gene expression circulating tumor DNA

文章选项

下载引文

分享