Objective: To investigate the value of comprehensive nursing intervention in shortening the indwelling time of urinary catheter after total hip arthroplasty (THR). Methods: Forty-three patients with THR treated from July 2015 to February 2016 were selected as a control group, and routine nursing intervention was adopted; 46 patients from March 2016 to April 2017 were selected as an observation group, and comprehensive nursing intervention was adopted. The time of postoperative analgesia pump, the postoperative pain, the indwelling time of the urinary catheter, the urination function and the subjective feeling of urination were compared between the two groups. Results: The indwelling time of analgesia pump and urinary catheter retention time in the observation group shortened significantly; there were no significant differences in pain scores at each time point and urinary tract infection after operation between the two groups (P>0.05). The first micturition function and the supervisor feeling of the observation group were better than that of the control group, the difference was statistically significant (P<0.05). Conclusion: The comprehensive nursing intervention program can effectively shorten the indwelling time of urinary catheter and indwelling time of the analgesic pump, promote the recovery of bladder function and improve the urination sensation of patients, and is worthy of clinical promotion.