Objective: To evaluate the efficacy and safety of psychological nursing on anxiety, depression and quality of life of patients with breast cancer through a Meta-analysis. Methods: All randomized controlled trials about evaluating the efficacy and safety of psychological nursing on anxiety, depression and quality of life of patients with breast cancer were searched on the database of Cochrane Library, Medline, PubMed, Embase, Ovid, CBM, VIP, Wanfang data and CNKI. Methodological quality assessment of the included literatures was performed using Cochrane risk evaluation tool. Software Stata 12.0 was used for meta-analysis. Results: A total of eight literatures involving 750 patients were identified. The number of psychological group and control patients was 376 and 374 respectively. Compared with control group, the psychological group was associated with less Self-Rating Anxiety Scale (SAS) score, Self-rating Depression Scale (SDS) score and more global quality of life (GQL) score, the difference was statistically significant (P<0.05). Conclusion: Psychological nursing can relieve anxiety and depression, and can improve the quality of life in breast cancer patients after surgery.