Objective: To compare the effect of two urethral catheterization procedures in patients after extensive hysterectomy. Methods: From April 2016 to March 2017 in our department, 74 cases of urinary retention with hysterectomy were randomly divided into an observation group and a control group, each with 37 cases, the control group used the routine catheterization management scheme, while the observation group used intermittent clean urethral catheter treatment scheme by the patients, and the incidence of urinary tract infection and retention of urine, the quality of life before and after intervention between the two groups were compared. Results: The urinary tract infection rate in the observation group was 5.41%, and without the occurrence of urinary retention, the incidence rate was significantly lower than that of the control group; the body pain, general health, social function, emotional function and mental health scores in the control group after intervention decreased significantly (P<0.05), while all dimensions of quality of life were significantly improved in the observation group (P<0.05), which was significantly better than those of the control group after intervention (P<0.05). Conclusion: Intermittent catheterization by the patients themselves is safe and can effectively reduce the incidence of urinary retention and urinary infection in patients after extensive hysterectomy, and improve the quality of life after extensive hysterectomy.