粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症1例
| 作者: |
1韩晓晓,
1闫冰迪,
1杨俊玲,
1林苏杰,
1张辉
1 吉林大学第二医院呼吸内科，长春 130000 |
| 通讯: |
杨俊玲
Email: junling@jlu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2017.08.038 |
摘要
收集1例肺泡蛋白沉积症(pulmonary alveolar proteinosis，PAP)患者临床资料并相关文献复习。患者因气短4个月，加重1个月入院，行纤维支气管镜活检。经过碘酸雪夫(Periodic acid-Schiff，PAS)染色阳性明确诊断为PAP，在经2次全肺灌洗治疗，病情反复后给予皮下注射粒细胞–巨噬细胞集落刺激因子，病情得到改善，提示对特发性PAP患者皮下注射粒细胞–巨噬细胞集落刺激因子是一种可行的治疗方法。
关键词：
肺泡蛋白沉积症
全肺灌洗
粒细胞–巨噬细胞集落刺激因子
One case of granulocyte-macrophage colony stimulating factor therapy for alveolar protein deposition
CorrespondingAuthor: YANG Junling Email: junling@jlu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.08.038
Abstract
The clinical data of 1 patient with pulmonary alveolar proteinosis were collected and the related literatures were reviewed. Patient was hospitalized with air shortness of time for 4 months, 1-month exacerbation, and did transbronchial biopsy. After Periodic acid-Schiff staining positive, the patient was diagnosed as pulmonary alveolar protein deposition. After the whole lung lavage for 2 times, the patient was given subcutaneous injection of granulocyte-macrophage colony stimulating factor after the disease repeating; the condition of the state improved as well. It suggests that subcutaneous injection of granulocyte-macrophage colony stimulating factor in idiopathic PAP patients is a viable method.
Keywords：
pulmonary alveolar proteinosis
whole lung lavage
granulocyte macrophage colony stimulating factor