Generally, it was believed that tumor progression was caused by a multistep process with genetic and epigenetic changes targeting only tumor cells. However, over the past two decades, the tumor microenvironment (TME) proved to play an equally important role in developing and establishing the morphology, growth and invasiveness of a malignancy. The TME includes local stromal cells, such as resident fibroblasts and macrophages, as well as distinct recruited cells such as endothedial cells, immune cells. Cancer-associated fobroblasts interact with tumor cells and additional components of the stroma, and once activated can induce vascular permeability and angiogenesis. Tumor-associated macrophages and tumor-associated neutrophils can exert protumoral functions, while inhibiting the antitumoral immune surveillance. Since the TME plays a key role in developing and establishing the morphology, growth and invasiveness, revealing the relationship between them might promote innovative treatments that make controlling metastasis possible.