文章摘要

白色脂肪“棕色化”调控因子FNDC5/Irisin的研究进展

作者: 1张潞, 1殷莲华
1 复旦大学上海医学院，上海 200032
通讯: 殷莲华 Email: lhyin@shmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.08.029

摘要

肥胖是当下全球牵涉范围最广的慢性疾病，也是2型糖尿病、心脑血管疾病以及某些癌症的重要风险因素。其中“白色脂肪棕色化”是目前该领域研究的热点之一，即将体内的储存多余能量的白色脂肪组织(white adipose tissue，WAT)转变为促进消耗能量的棕色脂肪组织(brown adipose tissue，BAT)。近年在肌细胞中发现的III型纤连蛋白组件包含蛋白5(fibronectin type III domain containing 5，FNDC5)经胞外切除形成小分子多肽，名为Irisin，具有“白色脂肪棕色化”的功能。
关键词： 纤连蛋白组件包含蛋白5 Irisin 棕色脂肪组织 白色脂肪组织 肥胖

Research progress in FNDC5/Irisin: browning regulator of white adipose tissue

Authors: 1ZHANG Lu, 1YIN Lianhua
1 Shanghai Medical College, Fudan University, Shanghai 200032, China

CorrespondingAuthor: YIN Lianhua Email: lhyin@shmu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2017.08.029

Abstract

Obesity is currently the most extensive chronic diseases in the world. It is also the risk factor of type 2 diabetes, cardiovascular diseases and some cancers. Changing white adipose tissue (WAT) into brown adipose tissue (BAT) is one of the hot spots in this filed. WAT storing excessive energy changes into BAT consuming energy. In recent years, people found fibronectin type III domain containing 5 (FNDC5) in muscle cells. FNDC5 by extracellular excision can form a small molecule polypeptide called Irisin which has the function of changing WAT into BAT.
Keywords： fibronectin type III domain containing 5 Irisin brown adipose tissue white adipose tissue obesity

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