Objective: To evaluate the effect of cognitive behavior therapy on depression and quality of life in patients with breast cancer through a meta-analysis. Methods: Medline, Cochrane library, EMBASE, PubMed, VIP, CBM, Chinese Wanfang database and CNKI database were manually searched. Any studies involving cognitive behavioral therapy and control group to improve depression after operation and life quality were picked. Self-Rating Anxiety Scale (SAS) score, Self-Rating Depression Scale (SDS) score and Quality of Life-Core 30 Questionnaire (QLQ-C30) score of each project were list as the main outcomes. Stata 12.0 was used for Meta-analysis. Results: A total of 17 articles were included in this study. Among them, there were 832 patients in the cognitive behavioral nursing group and 813 in the control group. Compared with the control group, the behavior cognitive therapy improved the postoperative depression and anxiety scores of breast carcinoma patients, and the differences between these two therapy methods was statistically significant (P<0.05). At the same time, cognitive behavior therapy improved the quality of life of patients after operation with statistically significant (P<0.05). Conclusion: Cognitive behavioral therapy can improve the quality of life of patients with breast cancer.