Objective: To analyze the clinical effect and the urodynamics of systemic bladder function training for patients after radical cystectomy of in situ sigmoid orthotopic neobladder. Methods: The clinical data of 80 patients who had undergone radical cystectomy of in situ sigmoid orthotopic neobladder in our hospital between May 2014 and May 2016 were analyzed. According to the different clinical training methods applied, these patients were assigned into two groups: the 40 cases treated with general bladder function training were taken as a control group, whereas the other 40 cases given systemic bladder function training as an observation group. The clinical effect and urinary dynamics in the two groups were compared. Results: In terms of urodynamic indexes, the residual urine volume, bladder capacity and maximum urine flow rate 9 months after the surgery were respectively better than that in the observation group, the difference was statistically significant (P<0.05); the incidence of complications (2.50%) after operation, including anastomotic stenosis of bladder ureter, uroclepsia during sleep and vesicoureteral reflux, in the observation group were lower than that (20.00%) in the control group, the difference was statistically significant (P<0.05); general health score (83.40±14.30) in the observation group were higher than that in the control group (65.33±13.10), the difference was statistically significant (P<0.05). Conclusion: For patients who had undergone radical cystectomy of in situ sigmoid orthotopic neobladder, systemic bladder function training can improve the urodynamics indexes, reduce postoperative complications and improve their quality of life.