文章摘要

常染色质组蛋白甲基化转移酶与哺乳动物生殖

作者: 1马妮, 1,2,3张昌军, 1,2,3邓锴, 1,2,3刁红录
1 湖北医药学院附属人民医院生殖医学中心，湖北 十堰 442000
2 湖北医药学院生物医学工程学院，湖北 十堰 442000
3 胚胎干细胞湖北省重点实验室，湖北 十堰 442000
通讯: 刁红录 Email: hldiao1976@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2017.07.029
基金: 国家自然科学基金, 31671565 湖北省自然科学基金, 2015CFB543 湖北医药学院创新团队, 2014CXX03，FDFR201604 湖北医药学院重点学科建设项目

摘要

常染色质组蛋白甲基化转移酶(euchromatin histone lysine methyltransferases，EHMTs)能够使基因组常染色质区域的组蛋白3第9位赖氨酸二甲基化(histone 3 9th lysine demethylate，H3K9-di)。在哺乳动物中有两种EHMT基因编码蛋白，分别为EHMT1编码GLP和EHMT2编码G9a。EHMTs在不同组织和不同细胞分化的过程中扮演不同的角色并且参与到记忆、药物成瘾、免疫反应等成人特异性反应过程的形成。EHMTs及其蛋白在哺乳动物生殖过程中的配子发生、胚胎发育及子宫疾病等方面发挥重要的作用。
关键词： 表观遗传 常染色质组蛋白甲基化转移酶 G9a 生殖发育

Euchromatin histone lysine methyltransferases and early mammalian development

Authors: 1MA Ni, 1,2,3ZHANG Changjun, 1,2,3DENG Kai, 1,2,3DIAO Honglu
1 Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan Hubei 442000
2 Biomedical Engineering College, Hubei University of Medicine, Shiyan Hubei 442000
3 Embryonic Stem Cells of Hubei Key Laboratory, Shiyan Hubei 442000, China

CorrespondingAuthor: DIAO Honglu Email: hldiao1976@hotmail.com

DOI: 10.3978/j.issn.2095-6959.2017.07.029

Abstract

Euchromatin histone lysine methyltransferases (EHMTs) can be known to making histone 3 9th lysine demethylate (H3K9-di) in the region of chromatin. In mammals, there are two kinds of proteins encoded by EHMT genes, EHMT1 encodes GLP and EHMT2 encodes G9a, respectively. EHMTs plays a different role in differentiation progress of various tissues and cells and also involves in the formation of adult specific reaction processes, such as memory, drug addiction, immunoreaction, etc. EHMTs and theirs proteins play an important role in gametogenesis, embryo development and uterine diseases of mammalian reproductive process.
Keywords： epigenetics euchromatin histone lysine methyltransferases G9a reproductive development

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