Septic cardiomyopathy is a complication of severe sepsis. The precise pathological mechanisms of septic cardiomyopathy remains incompletely understood. Mitochondrial dynamics are the processes of mitochondrial fusion and fission, which are regulated by a series of mitochondrial dynamics-related proteins. Recent emerging studies have revealed that abnormal mitochondrial fusion-fission balance can contributes to a variety of heart diseases, including septic cardiomyopathy. At present, there is no specific treatment for septic cardiomyopathy. The mitochondrial dysfunction is closely related to septic cardiomyopathy. Regulating mitochondrial dynamics is expected to be a new target for its intervention.