Objectives: To investigate the present clinical situation of patient confidence in communicating with doctors for young and middle-aged patients with sudden deafness, and to explore its influencing factors. Methods: A total of 142 young and middle-aged patients with sudden deafness, who were hospitalized in our hospital from January to December in 2015 were investigated by sequential sampling. During the investigation, General Condition Questionnaire and Chinese version of Patient Confidence in Communication Scale (PCCS) were adopted. Results: The PCCS score of young and middle-aged patients with sudden deafness was 16.41±5.53, and the average score of all items was 2.73±0.92, which was significantly lower than that of the national norm (3.76±0.67) (P<0.05). The result of multiple linear regression analysis showed that age, educational level, average monthly income and the degree of deafness were the main factors influencing patient confidence in communicating with doctors, which could explain 52.5% variability of variance components. Conclusion: As for young and middle-aged patients with sudden deafness, their confidence in communicating with doctors was insufficient. Clinicians and nurses should pay more attention to patients with the following characters: older, less educated, lower monthly income and more serious deafness. They should also prepare specific intervention strategies according to patient’s characteristics, to enhance the effectiveness of communication between doctors and patients and improve clinical treatment results.