肺腺鳞癌临床特征与预后因素
| 作者: |
1徐振武,
2徐倩,
3许春伟,
4王文娴,
1庄武
1 福建医科大学附属福建省肿瘤医院胸部肿瘤内科，福州 350014 2 福建医科大学附属协和医院肿瘤科，福州 350001 3 福建医科大学附属福建省肿瘤医院病理科，福州 350014 4 浙江省肿瘤医院胸部肿瘤内科，杭州 310022 |
| 通讯: |
许春伟
Email: xuchunweibbb@163.com 王文娴 Email: helen-0407@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.06.015 |
| 基金: | 国家临床重点专科建设项目, 2013 |
摘要
目的：探讨肺腺鳞癌的临床特征与预后因素。方法：回顾性分析95例肺腺鳞癌，分别对临床特征及基因状态进行分析，生存率用Kaplan-Meier方法计算，生存率显著性检验分析用Log-rank法，单因素和多因素分析用COX风险比例回归模型。结果：95例肺腺鳞癌，以男性、超过60岁和吸烟患者为主，应用COX风险比例回归模型对肺腺鳞癌的性别、年龄、吸烟史、EGFR基因突变状态、ALK融合基因状态、分期、亚型方式和亚型类型进行分析，结果显示分期、亚型方式和亚型类型是肺腺鳞癌独立的预后因素(P<0.05)。结论：肺腺鳞癌主要发生在60岁以上的男性吸烟患者，影响其预后的因素主要为分期、亚型方式和亚型类型。
关键词：
腺鳞癌
肺
EGFR基因
ALK基因
突变率
预后
Clinical features and prognostic factors of lung adenosquamous carcinoma
CorrespondingAuthor: XU Chunwei Email: xuchunweibbb@163.com
DOI: 10.3978/j.issn.2095-6959.2017.06.015
Abstract
Objective: To investigate the characteristics of lung adenosquamous carcinoma (ASC) and to analyze the prognostic factors. Methods: We retrospectively reviewed the clinical data and genetic state from 95 patients with ASC, and the survival rate was calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates. Univariate and multivariate factors for survival were analyzed by COX proportional hazards regression model. Results: Ninety-five cases of ASC were mainly men, more than 60 years old and smoking patients predominant; COX univariate analysis revealed that gender, age, smoking history, EGFR gene status, ALK fusion gene status, stage, subtype patterns and subtype type were prognostic factors for ASC. COX multivariate analysis found that stage, subtype patterns and subtype type were independent prognostic factors for ASC (P<0.05). Conclusion: ASC mainly occurred in men patients over 60 years old with smoking. Stage, subtype patterns and subtype type are the crucial prognostic factors for ASC.