文章摘要

FIZZ1在炎症相关性肺动脉高压中的作用

作者: 1,2王睿雯, 2,3戴爱国, 1,2蒋永亮
1 南华大学附属省马王堆医院呼吸内科，长沙 410016
2 湖南省老年医院呼吸疾病研究所，长沙 410016
3 长沙医学院呼吸疾病研究所，长沙 410219
通讯: 戴爱国 Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2017.06.035
基金: 国家自然科学基金, 81270118

摘要

低氧诱导促有丝分裂因子(hypoxia-induced mitogenic factor，HIMF)是一类富含半胱氨酸的分泌蛋白。HIMF首先在炎症区域被发现，并且扮演着炎症细胞标志物的角色，HIMF同时又称作发现于炎症区域1(found in inflammatory zone 1，FIZZ1)。由于该蛋白家族成员在低氧与炎症相关生理病理过程中起不可忽视的作用，国内外对该蛋白家族的研究越来越多。目前该因子在血管生长、平滑肌增殖、气道炎症、肠道免疫等方面的作用已有相关研究。
关键词： 低氧诱导促有丝分裂因子 肺动脉高压 炎症

Role of FIZZ1 in pulmonary hypertension induced by inflammation

Authors: 1,2WANG Ruiwen, 2,3DAI Aiguo, 1,2JIANG Yongliang
1 Department of Respiratory Medicine, Mawangdui Hospital Affiliated to South China University, Changsha 410016
2 Hunan Institute of Gerontology, Changsha 410016
3 Institute of Respiratory Diseases, Changsha Medical University, Changsha 410219, China

CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com

DOI: 10.3978/j.issn.2095-6959.2017.06.035

Abstract

Hypoxia induced mitogenic factor (HIMF) is a cysteine rich secretory protein. HIMF is first found in the inflammatory region and play a role in inflammatory cell markers. HIMF is also known to be found in inflammatory regions 1 (FIZZ1). As the members of the protein family play an important role in the physiological and pathological processes related to hypoxia and inflammation. There are more and more researches on the protein family at home and abroad. At present, the effect of this factor on vascular growth, smooth muscle proliferation, airway inflammation and intestinal immunity has been studied.

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